The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2015
Filed:
Feb. 17, 2011
Christopher Thomas Brain, North Reading, MA (US);
Young Shin Cho, Cambridge, MA (US);
John William Giraldes, Quincy, MA (US);
Bharat Lagu, Acton, MA (US);
Julian Roy Levell, Arlington, MA (US);
Michael J. Luzzio, Noank, CT (US);
Lawrence Blas Perez, Hopkinton, MA (US);
Yaping Wang, Boxborough, MA (US);
Fan Yang, West Roxbury, MA (US);
Christopher Thomas Brain, North Reading, MA (US);
Young Shin Cho, Cambridge, MA (US);
John William Giraldes, Quincy, MA (US);
Bharat Lagu, Acton, MA (US);
Julian Roy Levell, Arlington, MA (US);
Michael J. Luzzio, Noank, CT (US);
Lawrence Blas Perez, Hopkinton, MA (US);
Yaping Wang, Boxborough, MA (US);
Fan Yang, West Roxbury, MA (US);
Novartis AG, Basel, CH;
Abstract
The invention is directed to novel pyrrolopyrimidine compounds of formula (I) wherein R, R, R, R-R, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.