The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2015
Filed:
May. 02, 2012
Applicants:
Tomas Hudlicky, St. Catharines, CA;
Lukas Werner, Kadan, CZ;
Ales Machara, Brevnov, CZ;
Martina Wernerova, Svidnik, SK;
Mary Ann Endoma-arias, Quezon, PH;
Inventors:
Tomas Hudlicky, St. Catharines, CA;
Lukas Werner, Kadan, CZ;
Ales Machara, Brevnov, CZ;
Martina Wernerova, Svidnik, SK;
Mary Ann Endoma-Arias, Quezon, PH;
Assignee:
Brock University, St. Catharines, Ontario, CA;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/54 (2006.01); C07D 489/08 (2006.01);
U.S. Cl.
CPC ...
C07D 489/08 (2013.01);
Abstract
A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone.