The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 17, 2015

Filed:

Apr. 05, 2012
Applicants:

Scott Edmondson, Clark, NJ (US);

Zhiqiang Guo, Morganville, NJ (US);

Harold B. Wood, Westfield, NJ (US);

Andrew W. Stamford, Rahway, NJ (US);

Michael W. Miller, Scotch Plains, NJ (US);

Duane E. Demong, Somerset, NJ (US);

Gregori J. Morriello, Randolph, NJ (US);

Rajan Anand, Fanwood, NJ (US);

Vincent J. Colandrea, North Brunswick, NJ (US);

Megan Macala, Westfield, NJ (US);

Milana Maletic, Summit, NJ (US);

Cheng Zhu, Edison, NJ (US);

Yuping Zhu, Basking Ridge, NJ (US);

Wanying Sun, Edison, NJ (US);

Kake Zhao, Westfield, NJ (US);

Yong Huang, West Windsor, NJ (US);

Joel M. Harris, Minnetonka, MN (US);

Lehua Chang, Ramsey, NJ (US);

Nam Fung Kar, Brooklyn, NY (US);

Zhiyong HU, Livingston, NJ (US);

Liping Wang, Cranbury, NJ (US);

Bowei Wang, Westfield, NJ (US);

Ping Liu, Westfield, NJ (US);

Jason W. Szewczyk, Collegeville, PA (US);

William B. Geiss, Athens, NY (US);

Inventors:

Scott Edmondson, Clark, NJ (US);

Zhiqiang Guo, Morganville, NJ (US);

Harold B. Wood, Westfield, NJ (US);

Andrew W. Stamford, Rahway, NJ (US);

Michael W. Miller, Scotch Plains, NJ (US);

Duane E. DeMong, Somerset, NJ (US);

Gregori J. Morriello, Randolph, NJ (US);

Rajan Anand, Fanwood, NJ (US);

Vincent J. Colandrea, North Brunswick, NJ (US);

Megan Macala, Westfield, NJ (US);

Milana Maletic, Summit, NJ (US);

Cheng Zhu, Edison, NJ (US);

Yuping Zhu, Basking Ridge, NJ (US);

Wanying Sun, Edison, NJ (US);

Kake Zhao, Westfield, NJ (US);

Yong Huang, West Windsor, NJ (US);

Joel M. Harris, Minnetonka, MN (US);

Lehua Chang, Ramsey, NJ (US);

Nam Fung Kar, Brooklyn, NY (US);

Zhiyong Hu, Livingston, NJ (US);

Liping Wang, Cranbury, NJ (US);

Bowei Wang, Westfield, NJ (US);

Ping Liu, Westfield, NJ (US);

Jason W. Szewczyk, Collegeville, PA (US);

William B. Geiss, Athens, NY (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 513/04 (2006.01); C07D 401/12 (2006.01); C07D 413/14 (2006.01); C07D 413/04 (2006.01); C07D 211/22 (2006.01); C07D 405/04 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01); A61K 9/48 (2006.01); C07D 417/14 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); C07D 413/14 (2013.01); A61K 9/4858 (2013.01); C07D 401/12 (2013.01); C07D 413/04 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C07D 211/22 (2013.01); C07D 405/04 (2013.01);
Abstract

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.


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