The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2015
Filed:
Sep. 22, 2011
Applicants:
Gregory L. Verdine, Boston, MA (US);
Tom N. Grossmann, Dortmund, DE;
Tsung-han Johannes Yeh, Jamaica Plain, MA (US);
Inventors:
Gregory L. Verdine, Boston, MA (US);
Tom N. Grossmann, Dortmund, DE;
Tsung-Han Johannes Yeh, Jamaica Plain, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); C07K 14/47 (2006.01); C07K 1/113 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); C07K 14/47 (2013.01); C07K 14/4703 (2013.01); C07K 1/113 (2013.01); A61K 38/00 (2013.01);
Abstract
The invention relates to β-catenin targeting peptides comprising an α-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β-catenin targeting polypeptides including methods for treatment of disease, such as diseases associated with aberrant Wnt signaling, including cancer, are also provided.