The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 17, 2015

Filed:

Jan. 24, 2006
Applicants:

Philip E. Thorpe, Dallas, TX (US);

Troy A. Luster, Dallas, TX (US);

Steven W. King, Ladera Ranch, CA (US);

Inventors:

Philip E. Thorpe, Dallas, TX (US);

Troy A. Luster, Dallas, TX (US);

Steven W. King, Ladera Ranch, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 16/44 (2006.01); A61K 47/48 (2006.01); B82Y 5/00 (2011.01); C07K 14/775 (2006.01); C07K 16/30 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/44 (2013.01); A61K 47/48384 (2013.01); A61K 47/48415 (2013.01); A61K 47/48492 (2013.01); A61K 47/48507 (2013.01); A61K 47/48569 (2013.01); A61K 47/48753 (2013.01); B82Y 5/00 (2013.01); C07K 14/775 (2013.01); C07K 16/3076 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/77 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01);
Abstract

Disclosed are new phosphatidylserine binding constructs with surprising combinations of properties, and a range of diagnostic and therapeutic conjugates thereof. The new constructs effectively bind phosphatidylserine targets in disease and enhance their destruction, and can also specifically deliver attached imaging or therapeutic agents to the disease site. Also disclosed are methods of using the new construct compositions, therapeutic conjugates and combinations thereof in tumor vasculature targeting, cancer diagnosis and treatment, and for treating viral infections and other diseases.


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