The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 10, 2015

Filed:

Jan. 14, 2014
Applicant:

Arimed, Inc., Seoul, KR;

Inventors:

Dong Rack Choi, Yongin-si, KR;

Jin Yang, Yongin-si, KR;

Sue Hye Yoon, Suwon-si, KR;

Sung Jae Pyun, Seoul, KR;

Seung Hwan Kim, Suwon-si, KR;

Seung Kyoo Seong, Incheon, KR;

Jei Man Ryu, Anyang, KR;

Assignee:

Arimed, Inc., Seoul, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/4375 (2006.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); C07D 487/04 (2006.01); C07C 229/24 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 9/0019 (2013.01); A61K 9/145 (2013.01); A61K 9/2059 (2013.01); A61K 9/4858 (2013.01); A61K 31/4375 (2013.01); C07D 487/04 (2013.01); C07C 229/24 (2013.01);
Abstract

Disclosed herein are R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and L-aspartic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same for antimicrobial. Because the R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and L-aspartic acid salt is more soluble and less toxic and has less side effects as an antimicrobial agent than hydrochloride and the other salts (D-aspartate and phosphate) conventionally used, the salt may be useful for oral and injectable administration.


Find Patent Forward Citations

Loading…