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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8952157 B1

PDFFull Text
Date of Patent:
Feb. 10, 2015

Filed:

Jul. 26, 2013

Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Applicants:

Abbvie Inc., North Chicago, IL (US);

The Walter and Eliza Hall Institue of Medical Research, Parkville, AU;

Inventors:

Hong Ding, Gurnee, IL (US);

George A. Doherty, Libertyville, IL (US);

Steven W. Elmore, Northbrook, IL (US);

Laura Hexamer, Grayslake, IL (US);

Aaron R. Kunzer, Arlington Heights, IL (US);

Cheol-Min Park, Gurnee, IL (US);

Xiahong Song, Grayslake, IL (US);

Andrew J. Souers, Evanston, IL (US);

Gerard M. Sullivan, Lake Villa, IL (US);

Zhi-Fu Tao, Gurnee, IL (US);

Le Wang, Vernon Hills, IL (US);

Michael D. Wendt, Vernon Hills, IL (US);

Peter Edward Czabotar, North Melbourne, AU;

Guillaume Laurent Lessene, Bundoora, AU;

Peter Malcolm Colman, East Melbourne, AU;

Assignees:

AbbVie Inc., North Chicago, IL (US);

The Walter and Eliza Hall Institute of Medical Research, Victoria, AU;

Attorney:

Jones Day

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 241/12 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 209/08 (2006.01); C07D 211/58 (2006.01); C07D 213/74 (2006.01); C07D 213/84 (2006.01); C07D 231/56 (2006.01); C07D 235/06 (2006.01); C07D 277/24 (2006.01); C07D 295/30 (2006.01); C07D 309/04 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 309/08 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 209/08 (2013.01); C07D 211/58 (2013.01); C07D 213/74 (2013.01); C07D 213/84 (2013.01); C07D 231/56 (2013.01); C07D 235/06 (2013.01); C07D 277/24 (2013.01); C07D 295/30 (2013.01); C07D 309/04 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 309/08 (2013.01);
Abstract

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

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