The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2015
Filed:
Apr. 09, 2012
Mukund Keshav Gurjar, Pune, IN;
Golakchandra Sudarshan Maikap, Pune, IN;
Shashikant Gangaram Joshi, Pune, IN;
Sachin Aravind Badhe, Pune, IN;
Samit Satish Mehta, Pune, IN;
Mukund Keshav Gurjar, Pune, IN;
Golakchandra Sudarshan Maikap, Pune, IN;
Shashikant Gangaram Joshi, Pune, IN;
Sachin Aravind Badhe, Pune, IN;
Samit Satish Mehta, Pune, IN;
Emcure Pharmaceuticals Limited, Pune, IN;
Abstract
Disclosed is process for the preparation of a key Rilpivirine intermediate namely, (E)-4-(2-cyanoethenyl)-2,6-dimethylphenylamine hydrochloride (II) by a process comprising reaction of the tetrafluoroborate salt of the diazonium ion of 2,6-dimethyl-4-amino-1-carboxybenzyl phenylamine (VI) with acrylonitrile in presence of palladium acetate, followed by treatment with an acid and its subsequent conversion to the hydrochloride salt (II), wherein the undesired Z isomer is less than 0.5% and provides Rilpivirine hydrochloride having Z isomer less than 0.1%.