The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2015
Filed:
Apr. 03, 2014
Applicant:
Pharmathene Inc., Annapolis, MD (US);
Inventors:
Kalvin Yim, San Diego, CA (US);
Steven Danso, Bonsall, CA (US);
Edward Hausknecht, Annapolis, MD (US);
Assignee:
PharmAthene, Inc., Annapolis, MD (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C12N 15/00 (2006.01); C12N 5/071 (2010.01); C12N 15/52 (2006.01); C12N 9/18 (2006.01); C07H 21/00 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); C12N 15/66 (2006.01);
U.S. Cl.
CPC ...
C12N 15/52 (2013.01); C12N 9/18 (2013.01); C07K 2319/20 (2013.01); C07K 2319/35 (2013.01); C07H 21/00 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12N 15/63 (2013.01); C12N 15/66 (2013.01);
Abstract
Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (BChE) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated BChE molecules having selected properties, especially selective formation of monomers, are also described. Vectors and cells containing and/or expressing the nucleic acids are also disclosed.