The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2015
Filed:
Mar. 10, 2011
Applicants:
Donald W. Kufe, Wellesley, MA (US);
Surender Kharbanda, Natick, MA (US);
Inventors:
Donald W. Kufe, Wellesley, MA (US);
Surender Kharbanda, Natick, MA (US);
Assignees:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Genus Oncology, LLC, Chicago, IL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/35 (2006.01); C07K 5/103 (2006.01); C07D 311/02 (2006.01); A61K 31/353 (2006.01); C07K 5/083 (2006.01); C07K 7/06 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 5/1013 (2013.01); C07D 311/02 (2013.01); A61K 31/35 (2013.01); A61K 31/353 (2013.01); C07K 5/081 (2013.01); C07K 7/06 (2013.01); G01N 33/5011 (2013.01); G01N 33/57496 (2013.01); G01N 33/6872 (2013.01); G01N 2333/4725 (2013.01); G01N 2500/04 (2013.01);
Abstract
The invention provides methods for the identification of small molecules that inhibit MUC1 oligomerization, and the functions flowing therefrom. In addition, small molecules that prevent MUC1 oligomerization are disclosed. Identified molecules will find use in treating a variety of MUC1-related inflammatory conditions, including MUC1-related cancers.