The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2015
Filed:
Aug. 19, 2010
Claus Kremoser, Heidelberg, DE;
Ulrich Abel, Bad Homburg, DE;
Christoph Steeneck, Dossenheim, DE;
Olaf Kinzel, Heidelberg, DE;
Claus Kremoser, Heidelberg, DE;
Ulrich Abel, Bad Homburg, DE;
Christoph Steeneck, Dossenheim, DE;
Olaf Kinzel, Heidelberg, DE;
Phenex Pharmaceuticals AG, Ludwigshafen, DE;
Abstract
The present invention relates to compounds of formula (1): where R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.