The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 10, 2015

Filed:

Aug. 02, 2013
Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Kaustav Biswas, Agoura Hills, CA (US);

Jian J. Chen, Camarillo, CA (US);

Vijay Keshav Gore, Aliso Viejo, CA (US);

Scott Harried, Pittsburgh, PA (US);

Daniel B. Horne, Simi Valley, CA (US);

Matthew R. Kaller, Ventura, CA (US);

Vu Van Ma, Oak Park, CA (US);

Kelvin Sham, Thousand Oaks, CA (US);

Wenge Zhong, Thousand Oaks, CA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 491/052 (2006.01); C07D 401/12 (2006.01); C07D 311/68 (2006.01); C07D 215/40 (2006.01); C07D 471/04 (2006.01); C07D 491/04 (2006.01);
U.S. Cl.
CPC ...
C07D 491/052 (2013.01); C07D 401/12 (2013.01); C07D 311/68 (2013.01); C07D 215/40 (2013.01); C07D 471/04 (2013.01); C07D 491/04 (2013.01);
Abstract

Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.


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