The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 10, 2015

Filed:

Oct. 20, 2010
Applicants:

Henning Priepke, Warthausen, DE;

Henri Doods, Warthausen, DE;

Raimund Kuelzer, Mittlelbiberach, DE;

Roland Pfau, Biberach, DE;

Dirk Stenkamp, Biberach, DE;

Robert Roenn, Uppsala, SE;

Benjamin Pelcman, Uppsala, SE;

Inventors:

Henning Priepke, Warthausen, DE;

Henri Doods, Warthausen, DE;

Raimund Kuelzer, Mittlelbiberach, DE;

Roland Pfau, Biberach, DE;

Dirk Stenkamp, Biberach, DE;

Robert Roenn, Uppsala, SE;

Benjamin Pelcman, Uppsala, SE;

Assignee:

Orexo AB, Stockholm, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/445 (2006.01); C07D 211/32 (2006.01); C07C 311/14 (2006.01); C07D 213/82 (2006.01); C07C 237/42 (2006.01); C07C 237/44 (2006.01); C07C 255/23 (2006.01); C07C 255/60 (2006.01); C07D 205/04 (2006.01); C07D 207/10 (2006.01); C07D 207/22 (2006.01); C07D 207/34 (2006.01); C07D 209/08 (2006.01); C07D 211/14 (2006.01); C07D 211/16 (2006.01); C07D 211/18 (2006.01); C07D 211/38 (2006.01); C07D 213/40 (2006.01); C07D 213/75 (2006.01); C07D 213/81 (2006.01); C07D 215/42 (2006.01); C07D 237/30 (2006.01); C07D 277/46 (2006.01); C07D 277/56 (2006.01); C07D 277/60 (2006.01); C07D 277/82 (2006.01); C07D 295/15 (2006.01); C07D 295/155 (2006.01); C07D 307/20 (2006.01); C07D 307/24 (2006.01); C07D 309/12 (2006.01); C07D 309/14 (2006.01); C07D 333/38 (2006.01); C07D 335/02 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
C07D 213/82 (2013.01); C07C 237/42 (2013.01); C07C 237/44 (2013.01); C07C 255/23 (2013.01); C07C 255/60 (2013.01); C07C 311/14 (2013.01); C07D 205/04 (2013.01); C07D 207/10 (2013.01); C07D 207/22 (2013.01); C07D 207/34 (2013.01); C07D 209/08 (2013.01); C07D 211/14 (2013.01); C07D 211/16 (2013.01); C07D 211/18 (2013.01); C07D 211/38 (2013.01); C07D 213/40 (2013.01); C07D 213/75 (2013.01); C07D 213/81 (2013.01); C07D 215/42 (2013.01); C07D 237/30 (2013.01); C07D 277/46 (2013.01); C07D 277/56 (2013.01); C07D 277/60 (2013.01); C07D 277/82 (2013.01); C07D 295/15 (2013.01); C07D 295/155 (2013.01); C07D 307/20 (2013.01); C07D 307/24 (2013.01); C07D 309/12 (2013.01); C07D 309/14 (2013.01); C07D 333/38 (2013.01); C07D 335/02 (2013.01); C07D 417/04 (2013.01); C07C 2101/02 (2013.01); C07C 2101/04 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01);
Abstract

This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain. A, M, R, R, R, R, R, Q, Q, Q, Z, Z, Z, Zand W have meanings given in the description.


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