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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8951937 B1

PDFFull Text
Date of Patent:
Feb. 10, 2015

Filed:

Mar. 15, 2013

Identification and use of bacterial [2fe-2s] dihydroxy-acid dehydratases

Applicant:

Butamax(tm) Advanced Biofuels Llc, Wilmington, DE (US);

Inventors:

Dennis Flint, Newark, DE (US);

Steven Cary Rothman, Wilmington, DE (US);

Wonchul Suh, Hockessin, DE (US);

Jean-Francois Tomb, Wilmington, DE (US);

Rick W. Ye, Hockessin, DE (US);

Assignee:

Butamax Advanced Biofuels LLC, Wilmington, DE (US);

Attorney:
Primary Examiner:

Delia Ramirez

Int. Cl.
CPC ...
C40B 30/00 (2006.01); C12P 21/00 (2006.01); G06F 19/22 (2011.01); C12P 7/16 (2006.01); C12P 7/40 (2006.01); C12P 13/06 (2006.01); C12P 13/08 (2006.01); C12N 1/21 (2006.01); C12N 1/19 (2006.01); C12N 9/88 (2006.01); C12N 15/00 (2006.01); C12N 5/10 (2006.01);
U.S. Cl.
CPC ...
G06F 19/22 (2013.01); C12N 9/88 (2013.01); C12P 7/16 (2013.01); C12P 7/40 (2013.01); C12P 13/06 (2013.01); C12P 13/08 (2013.01); C12Y 402/01009 (2013.01); Y02E 50/10 (2013.01);
Abstract

A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing DHAD activity for conversion of 2,3-dihydroxyisovalerate to α-ketoisovalerate or 2,3-dihydroxymethylvalerate to α-ketomethylvalerate. Isobutanol and other compounds may be synthesized in pathways that include bacterial [2Fe-2S] DHAD activity.

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Flint, Dennis. (2015). Identification and use of bacterial [2fe-2s] dihydroxy-acid dehydratases (U.S. Patent No. 8951937). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8951937

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