The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2015
Filed:
May. 05, 2014
Applicant:
The Kingdom of the Netherlands, Represented BY the Minister of Health, Welfare and Sport, Bilthoven, NL;
Inventors:
Eliud Oloo, Toronto, CA;
Raymond Oomen, Toronto, CA;
Martina Ochs-Onolemhemhen, Lyons, FR;
Jeremy Yethon, Toronto, CA;
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 39/09 (2006.01); A61K 39/38 (2006.01); C07K 14/315 (2006.01); C07K 16/12 (2006.01);
U.S. Cl.
CPC ...
C07K 14/3156 (2013.01); C07K 16/1275 (2013.01); A61K 39/092 (2013.01); C07K 2317/76 (2013.01);
Abstract
This disclosure relates to modifiedpneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused byThe modified pneumolysm proteins comprise amino acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.