The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2015
Filed:
Dec. 21, 2010
Applicant:
Shu-hsia Chen, New York, NY (US);
Inventor:
Shu-Hsia Chen, New York, NY (US);
Assignee:
Icahn School of Medicine at Mount Sinai, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/02 (2006.01); A61K 35/14 (2006.01); A61K 31/137 (2006.01); A61K 31/395 (2006.01); A61K 31/416 (2006.01); A61K 31/465 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01);
U.S. Cl.
CPC ...
A61K 38/02 (2013.01); A61K 31/137 (2013.01); A61K 31/395 (2013.01); A61K 31/416 (2013.01); A61K 31/465 (2013.01); A61K 38/18 (2013.01); A61K 38/193 (2013.01); A61K 35/15 (2013.01);
Abstract
Methods for enhancing the suppressive function of myeloid derived suppressor cells (MDSCs) for the treatment of autoimmune diseases using small compounds are disclosed. In certain aspects, the small compounds are glatiramer acetate and mitogen activated protein (MAP) kinase inhibitors. In other aspects, these methods include the administration of exogenous MDSCs or the use of endogenous MDSCs mobilized using stem cell mobilizers. In yet other aspects, compositions containing MDSCs and small compounds of the invention are provided.