The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2015
Filed:
Aug. 20, 2010
Applicants:
Andreas Arnell, Cambridge, GB;
Jose Jimenez, London, GB;
Rebecca Michael, Cambridge, GB;
Yvette Stallwood, Suffolk, GB;
Jesus Zurdo, Cambridge, GB;
Inventors:
Andreas Arnell, Cambridge, GB;
Jose Jimenez, London, GB;
Rebecca Michael, Cambridge, GB;
Yvette Stallwood, Suffolk, GB;
Jesus Zurdo, Cambridge, GB;
Assignee:
Lonza Biologics PLC, Slough, Berkshire, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); A61K 39/39591 (2013.01); C07K 2317/522 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01);
Abstract
This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.