The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
Oct. 13, 2011
Jagapathi Raju Srivatsavayi, Hyderabad, IN;
Sairam Pothukuchi, Hyderabad, IN;
Srinivasa Sastry Rani, Hyderabad, IN;
Mallikarjuna Rao Chikka, Hyderabad, IN;
Chiranjeevi Cheekati, Hyderabad, IN;
Mallikarjuna Rao Gutti, Hyderabad, IN;
Trimurthulu Singavarapu, Hyderabad, IN;
Venkat Reddy Thimmaipally, Hyderabad, IN;
Venkateswara Rao Tadanki, Hyderabad, IN;
Jagapathi Raju Srivatsavayi, Hyderabad, IN;
Sairam Pothukuchi, Hyderabad, IN;
Srinivasa Sastry Rani, Hyderabad, IN;
Mallikarjuna Rao Chikka, Hyderabad, IN;
Chiranjeevi Cheekati, Hyderabad, IN;
Mallikarjuna Rao Gutti, Hyderabad, IN;
Trimurthulu Singavarapu, Hyderabad, IN;
Venkat Reddy Thimmaipally, Hyderabad, IN;
Venkateswara Rao Tadanki, Hyderabad, IN;
Vijayasri Organics Limited, Hyderabad, IN;
Abstract
A process for preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butane amide also known as a diketone intermediate of atorvastatin, completely devoid of impurities 3,4-difluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-n-β-diphenylbenzene butane amide; methyl, 2{-2[-(4-fluorophenyl)-2-oxo-1-phenylethyl)]}-4-methyl-3-oxo pentanoate; 1,4-bis(4-fluorophenyl)-2,3-diphenylbutane-1,4-dione, 1-(4-fluorophenyl)-2-phenyl ethanone; 1-(4-fluorophenyl)-2-phenyl ethanone and containing about 0.05% or less of 2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butane amide. In that process the said diketone intermediate of formula 1 is obtained by maintaining temperature −25° C. to 50° C. during Friedel-Crafts acylation, in situ halogenation of formula II in presence of a solvent and nucleophilic substitution from a compound of formula III with formula IV in presence of a base.