The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
Apr. 29, 2011
Umberto Ciambecchini, Patrica, IT;
Stefano Turchetta, Patrica, IT;
Lorenzo DE Ferra, Patrica, IT;
Maurizio Zenoni, Patrica, IT;
Umberto Ciambecchini, Patrica, IT;
Stefano Turchetta, Patrica, IT;
Lorenzo De Ferra, Patrica, IT;
Maurizio Zenoni, Patrica, IT;
Chemi S.p.A., Cinisello Balsamo (MI), IT;
Abstract
The present invention regards an improved and industrially advantageous process for the preparation of the 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called 'feso chromenyl' and (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, also called '(R)-feso deacyl', which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine fumarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate “(R)-feso deacyl”, called form B.