The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
Sep. 15, 2011
Brian Orr, O'Fallon, MO (US);
Joseph P. Haar, Jr., Edwardsville, IL (US);
George H. Klemm, Webster Groves, MO (US);
Keith G. Tomazi, Florissant, MO (US);
Brian Orr, O'Fallon, MO (US);
Joseph P. Haar, Jr., Edwardsville, IL (US);
George H. Klemm, Webster Groves, MO (US);
Keith G. Tomazi, Florissant, MO (US);
Mallinckrodt LLC, Hazelwood, MO (US);
Abstract
The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.