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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8946429 B1

PDFFull Text
Date of Patent:
Feb. 03, 2015

Filed:

Dec. 07, 2010

Kinetic resolution

Applicants:

Stephen Joseph Connon, Dublin, IE;

Aldo Peschiulli, Lecce, IT;

Barbara Procuranti, Marina di Carrara, IT;

Inventors:

Stephen Joseph Connon, Dublin, IE;

Aldo Peschiulli, Lecce, IT;

Barbara Procuranti, Marina di Carrara, IT;

Assignee:

The Provost, Fellows, Foundation Scholars, and the other Members of the Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin, Dublin, IE;

Attorney:

Scully, Scott, Murphy & Presser, P.C.

Primary Examiner:

D M Seaman

Int. Cl.
CPC ...
C07C 319/28 (2006.01); C07C 319/02 (2006.01); C07C 231/18 (2006.01); C07C 227/32 (2006.01); C07C 327/28 (2006.01); C07C 319/12 (2006.01); C07D 453/04 (2006.01); C07C 327/22 (2006.01); C07B 57/00 (2006.01);
U.S. Cl.
CPC ...
C07C 319/12 (2013.01); C07C 319/02 (2013.01); C07C 231/18 (2013.01); C07B 2200/07 (2013.01); C07C 227/32 (2013.01); C07C 327/28 (2013.01); C07D 453/04 (2013.01); C07C 319/28 (2013.01); C07C 327/22 (2013.01); C07B 57/00 (2013.01);
Abstract

While methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.

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