The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
Mar. 26, 2007
Jacquelyn Gervay-hague, Davis, CA (US);
Wenjun Du, St. Louis, MO (US);
Sally Denardo, El Macero, CA (US);
Arutselvan Natarajan, Sacramento, CA (US);
Jacquelyn Gervay-Hague, Davis, CA (US);
Wenjun Du, St. Louis, MO (US);
Sally Denardo, El Macero, CA (US);
Arutselvan Natarajan, Sacramento, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking.