Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use

Abstract

The invention relates to compounds of Formula (I): (A')-(A)-(B)—(Z)-(L)-C(═O)NHor pharmaceutically acceptable salts or solvates thereof, wherein: (A) is heteroaryl or aryl; each (A′), if present, is indepedently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2 or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, sulfinyl, and carboxamide; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; and (L) is —(CH)CR,R—, wherein m is 0, 1, 2, 3, 4, 5, or 6, and wherein Rand Rare each independently hydrogen or C-Calkyl; provided that, if (L) is —CH— or —CH(CH)—, then X is not 0. The compounds of the invention are useful in the treatment of diseases such as cancer and neurodegenerative diseases.