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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8946259 B1

PDFFull Text
Date of Patent:
Feb. 03, 2015

Filed:

Oct. 28, 2013

Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors

Applicant:

High Point Pharmaceuticals, Llc, High Point, NC (US);

Inventors:

Adnan M. M. Mjalli, Oak Ridge, NC (US);

David Robert Jones, Milford, OH (US);

Devi Reddy Gohimukkula, Jamestown, NC (US);

Guoxiang Huang, Kernersville, NC (US);

Jeff Jiqun Zhu, Winston-Salem, NC (US);

Mohan Rao, Greensboro, NC (US);

Robert Carl Andrews, Jamestown, NC (US);

Tan Ren, Colfax, NC (US);

Assignee:

High Point Pharmaceuticals, LLC, High Point, NC (US);

Attorney:

Samuel B. Rollins

Primary Examiner:

Robert Havlin

Int. Cl.
CPC ...
C07D 401/12 (2006.01); A61K 31/4725 (2006.01); C07D 401/14 (2006.01); C07D 235/30 (2006.01); C07D 401/04 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 407/14 (2006.01); C07D 409/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 473/00 (2006.01); C07D 491/04 (2006.01); C07D 495/04 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/4725 (2013.01); C07D 235/30 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 407/14 (2013.01); C07D 409/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 473/00 (2013.01); C07D 491/04 (2013.01); C07D 495/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.

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