The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 03, 2015

Filed:

Nov. 16, 2010
Applicants:

Chung K. Chu, Statham, GA (US);

Jianing Wang, Murrieta, CA (US);

Inventors:

Chung K. Chu, Statham, GA (US);

Jianing Wang, Murrieta, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/52 (2006.01); A61K 31/675 (2006.01); A61K 31/7068 (2006.01); C07D 473/34 (2006.01); C07F 9/24 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 473/34 (2013.01); A61K 45/06 (2013.01);
Abstract

The present invention relates to 2'-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Hepatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses.


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