The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
Aug. 05, 2010
Elisabeth Dupont-passelaigue, Castres, FR;
Samuel Mialhe, Castres, FR;
Jean-pierre Rieu, Castres, FR;
Didier Junquero, Castres, FR;
Karine Valeille, Palaiseau, FR;
Elisabeth Dupont-Passelaigue, Castres, FR;
Samuel Mialhe, Castres, FR;
Jean-Pierre Rieu, Castres, FR;
Didier Junquero, Castres, FR;
Karine Valeille, Palaiseau, FR;
Pierre Fabre Medicament, Boulogne-Billancourt, FR;
Abstract
The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: —Rrepresents one or more groups such as: trifluoromethyl, halogen such as F, Cl, —when n=m=1, W represents CH then Y represents oxygen, —U represents: •either —(C═O)CHNH— and is branched at position 4 of pyridazinone, then R2 represents H, •or —(C═O)NH— and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, —R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enzyme inhibitors for the treatment of obesity, type-2 diabetes and lipid disorders.