The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 03, 2015

Filed:

Nov. 11, 2011
Applicants:

Mark Craighead, Manchester, GB;

Ronald Palin, Manchester, GB;

Neil Murray, Manchester, GB;

Derek Lindsay, Manchester, GB;

Inventors:

Mark Craighead, Manchester, GB;

Ronald Palin, Manchester, GB;

Neil Murray, Manchester, GB;

Derek Lindsay, Manchester, GB;

Assignee:

Redx Pharma Limited, Liverpool, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); C07D 487/04 (2006.01); C07D 498/06 (2006.01); C07D 413/12 (2006.01); C07C 63/64 (2006.01); C07D 213/60 (2006.01); C07C 217/58 (2006.01); C07D 403/06 (2006.01); C07C 69/12 (2006.01); C07C 235/16 (2006.01); C07D 257/04 (2006.01); C07D 313/04 (2006.01); C07D 407/06 (2006.01); C07C 43/205 (2006.01); C07C 215/46 (2006.01); C07C 255/25 (2006.01); C07D 205/08 (2006.01); C07D 281/06 (2006.01); C07D 417/06 (2006.01); C07D 413/04 (2006.01); C07D 401/04 (2006.01); C07C 63/66 (2006.01); C07D 499/88 (2006.01); C07D 401/12 (2006.01); C07D 519/00 (2006.01); C07D 209/18 (2006.01); C07D 307/00 (2006.01); C07D 501/00 (2006.01); C07C 233/22 (2006.01); C07D 473/00 (2006.01); C07H 19/052 (2006.01); C07C 251/40 (2006.01); C07D 403/12 (2006.01); C07D 513/06 (2006.01); C07C 251/54 (2006.01); C07C 257/14 (2006.01); C07C 251/48 (2006.01); C07C 57/00 (2006.01); C07C 233/36 (2006.01); C07H 19/173 (2006.01); C07D 411/10 (2006.01); C07C 229/18 (2006.01); C07D 295/02 (2006.01); C07H 19/06 (2006.01); C07C 235/28 (2006.01); C07D 233/54 (2006.01); C07J 5/00 (2006.01); C07D 471/04 (2006.01); C07D 241/04 (2006.01); C07D 235/16 (2006.01); C07D 277/40 (2006.01); C07D 417/12 (2006.01); C07D 309/32 (2006.01); C07C 237/20 (2006.01); C07C 251/58 (2006.01); C07D 401/14 (2006.01); C07D 491/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 498/06 (2013.01); C07D 413/12 (2013.01); C07C 63/64 (2013.01); C07D 213/60 (2013.01); C07C 217/58 (2013.01); C07D 403/06 (2013.01); C07C 69/12 (2013.01); C07C 235/16 (2013.01); C07D 257/04 (2013.01); C07D 313/04 (2013.01); C07D 407/06 (2013.01); C07C 2102/10 (2013.01); C07C 43/205 (2013.01); C07C 215/46 (2013.01); C07C 255/25 (2013.01); C07D 205/08 (2013.01); C07D 281/06 (2013.01); C07D 417/06 (2013.01); C07D 413/04 (2013.01); C07D 401/04 (2013.01); C07C 63/66 (2013.01); C07D 499/88 (2013.01); C07D 401/12 (2013.01); C07C 2101/16 (2013.01); C07D 519/00 (2013.01); C07D 209/18 (2013.01); C07D 307/00 (2013.01); C07D 501/00 (2013.01); C07C 233/22 (2013.01); C07D 473/00 (2013.01); C07H 19/052 (2013.01); C07C 251/40 (2013.01); C07D 403/12 (2013.01); C07D 513/06 (2013.01); C07C 2103/74 (2013.01); C07C 251/54 (2013.01); C07C 257/14 (2013.01); C07C 251/48 (2013.01); C07C 57/00 (2013.01); C07C 233/36 (2013.01); C07H 19/173 (2013.01); C07D 411/10 (2013.01); C07C 229/18 (2013.01); C07D 295/02 (2013.01); C07H 19/06 (2013.01); C07C 235/28 (2013.01); C07D 233/54 (2013.01); C07J 5/00 (2013.01); C07D 471/04 (2013.01); C07D 241/04 (2013.01); C07D 235/16 (2013.01); C07D 277/40 (2013.01); C07D 417/12 (2013.01); C07D 309/32 (2013.01); C07C 237/20 (2013.01); C07C 251/58 (2013.01); C07D 401/14 (2013.01); C07D 491/04 (2013.01);
Abstract

The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more reactions which may be considered to represent a change of oxidation state. We refer to these compounds generally as redox derivatives. The derivatives of the invention may be related to the original parent active pharmaceutical compound by only a single step transformation, or may be related via several synthetic steps including one or more changes of oxidation state. Exemplary derivatives have the formula


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