The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 03, 2015

Filed:

Mar. 05, 2013
Applicants:

Asitha Abeywardane, Danbury, CT (US);

Steven Richard Brunette, New Milford, CT (US);

Michael J. Burke, Cheshire, CT (US);

Suresh R. Kapadia, Danbury, CT (US);

Thomas Martin Kirrane, Middlebury, CT (US);

Matthew Russell Netherton, Danbury, CT (US);

Hossein Razavi, Danbury, CT (US);

Sonia Rodriguez, New Milford, CT (US);

Anjan Saha, Hamden, CT (US);

Robert Sibley, North Haven, CT (US);

Lana Louise Smith-keenan, Poughquag, NY (US);

Hidenori Takahashi, LaGrangeville, NY (US);

Michael Robert Turner, Danbury, CT (US);

Jiang-ping Wu, Danbury, CT (US);

Erick Richard Roush Young, Danbury, CT (US);

Qiang Zhang, Woodbury, CT (US);

Qing Zhang, Tianjin, CH;

Renee M. Zindell, New Milford, CT (US);

Inventors:

Asitha Abeywardane, Danbury, CT (US);

Steven Richard Brunette, New Milford, CT (US);

Michael J. Burke, Cheshire, CT (US);

Suresh R. Kapadia, Danbury, CT (US);

Thomas Martin Kirrane, Middlebury, CT (US);

Matthew Russell Netherton, Danbury, CT (US);

Hossein Razavi, Danbury, CT (US);

Sonia Rodriguez, New Milford, CT (US);

Anjan Saha, Hamden, CT (US);

Robert Sibley, North Haven, CT (US);

Lana Louise Smith-Keenan, Poughquag, NY (US);

Hidenori Takahashi, LaGrangeville, NY (US);

Michael Robert Turner, Danbury, CT (US);

Jiang-Ping Wu, Danbury, CT (US);

Erick Richard Roush Young, Danbury, CT (US);

Qiang Zhang, Woodbury, CT (US);

Qing Zhang, Tianjin, CH;

Renee M. Zindell, New Milford, CT (US);

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/00 (2006.01); C07D 491/04 (2006.01); C07D 487/08 (2006.01); A61K 31/357 (2006.01); C07D 491/052 (2006.01); C07D 405/10 (2006.01); C07D 295/096 (2006.01); C07D 295/155 (2006.01); C07D 513/04 (2006.01); C07D 405/14 (2006.01); C07D 319/20 (2006.01); C07D 405/12 (2006.01); C07D 487/10 (2006.01); C07D 413/10 (2006.01); C07D 417/10 (2006.01); C07D 417/14 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 491/052 (2013.01); C07D 405/10 (2013.01); C07D 295/096 (2013.01); C07D 295/155 (2013.01); C07D 513/04 (2013.01); C07D 405/14 (2013.01); A61K 31/357 (2013.01); C07D 319/20 (2013.01); C07D 405/12 (2013.01); C07D 487/10 (2013.01); C07D 413/10 (2013.01); C07D 417/10 (2013.01); C07D 417/14 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 491/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention relates to compounds of formula (I): wherein Rto R, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene Ahydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.


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