The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
Jun. 17, 2011
Applicants:
Hirohiko Hohjoh, Tokyo, JP;
Masaki Takahashi, Tokyo, JP;
Inventors:
Hirohiko Hohjoh, Tokyo, JP;
Masaki Takahashi, Tokyo, JP;
Assignee:
LSIP, LLC, Tokyo, JP;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12Q 1/68 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/533 (2013.01); C12N 2320/34 (2013.01);
Abstract
An agent for selectively suppressing the expression of a dominant allele while allowing expression of wild-type or desired alleles and methods for using the agent are described. The RNAi agent has a structure obtained by assigning a dominant point mutation in the targeted allele as a standard point, setting a base length from the standard point to the 5' end to a predetermined length, and introducing one mismatch base differing from the target sequence to a predetermined position downstream from the standard point.