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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8946185 B1

PDFFull Text
Date of Patent:
Feb. 03, 2015

Filed:

Jun. 17, 2011

Agent for suppressing expression of dominant allele

Applicants:

Hirohiko Hohjoh, Tokyo, JP;

Masaki Takahashi, Tokyo, JP;

Inventors:

Hirohiko Hohjoh, Tokyo, JP;

Masaki Takahashi, Tokyo, JP;

Assignee:

LSIP, LLC, Tokyo, JP;

Attorneys:

Edwards Wildman Palmer LLP

David G. Conlin

George W. Neuner

Primary Examiner:

Tracy Vivlemore

Assistant Examiner:

Kate Poliakova

Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12Q 1/68 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/533 (2013.01); C12N 2320/34 (2013.01);
Abstract

An agent for selectively suppressing the expression of a dominant allele while allowing expression of wild-type or desired alleles and methods for using the agent are described. The RNAi agent has a structure obtained by assigning a dominant point mutation in the targeted allele as a standard point, setting a base length from the standard point to the 5' end to a predetermined length, and introducing one mismatch base differing from the target sequence to a predetermined position downstream from the standard point.

Find Patent Forward Citations

Hohjoh, Hirohiko. (2015). Agent for suppressing expression of dominant allele (U.S. Patent No. 8946185). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8946185

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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