The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
Dec. 19, 2012
Applicants:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, CA (US);
Inventors:
Brenda F. Baker, Carlsbad, CA (US);
Adrian R. Krainer, Huntington Station, NY (US);
Yimin Hua, Jericho, NY (US);
Assignee:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 31/70 (2006.01); C12N 15/113 (2010.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 15/111 (2013.01); C12N 2310/11 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3341 (2013.01); C12N 2320/33 (2013.01);
Abstract
Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.