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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8945547 B1

PDFFull Text
Date of Patent:
Feb. 03, 2015

Filed:

Mar. 14, 2013

Notch1 receptor antibodies and methods of treatment

Applicant:

Oncomed Pharmaceuticals, Inc., Redwood City, CA (US);

Inventors:

Austin L. Gurney, San Francisco, CA (US);

Timothy Charles Hoey, Hillsborough, CA (US);

Maureen Fitch Bruhns, San Mateo, CA (US);

Fumiko Takada Axelrod, Palo Alto, CA (US);

Assignee:

OncoMed Pharmaceuticals, Inc., Redwood City, CA (US);

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Bridget E Bunner

Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); C07H 21/04 (2006.01); C12N 5/10 (2006.01); C12N 5/12 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12N 15/13 (2006.01); C07K 16/30 (2006.01); A61K 45/06 (2006.01); C07K 16/46 (2006.01); C07K 16/22 (2006.01); C12P 21/08 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 14/435 (2006.01); C12N 15/63 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); C07K 16/28 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); C07K 16/462 (2013.01); C07K 16/464 (2013.01); C07K 16/22 (2013.01); C07K 14/435 (2013.01); C12N 15/63 (2013.01); C12N 15/79 (2013.01); C07H 21/04 (2013.01); C12N 5/12 (2013.01); A61K 39/3955 (2013.01); C07K 14/71 (2013.01); A61K 2039/505 (2013.01); C07K 2316/96 (2013.01); C07K 2317/56 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01);
Abstract

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

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