The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2015
Filed:
Jul. 25, 2011
Chad Dickey, Tampa, FL (US);
Matthew Lebar, Boston, MA (US);
Bill J. Baker, Tampa, FL (US);
Jeffrey Jones, Madison, WI (US);
Chad Dickey, Tampa, FL (US);
Matthew Lebar, Boston, MA (US);
Bill J. Baker, Tampa, FL (US);
Jeffrey Jones, Madison, WI (US);
University of South Florida, Tampa, FL (US);
Abstract
The subject invention provides a myricanol compound that is in predominant form of (+)-αR,11S-myricanol as compared to (−)-αS,11R-myricanol. In one embodiment, the (+)-αR,11S-myricanol is isolated from, and is in about 86% enantiomeric excess of (−)-αS,11R-myricanol. The subject invention also pertains to therapeutic compositions and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. Specifically exemplified herein is the therapeutic use of myricanol and myricanone isolated from root barks ofspecies. Also provided are methods for preparing extracts of the subject invention fromspecies.