The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2015
Filed:
Aug. 01, 2012
Yong-chul Kim, Gwangju, KR;
Hyo Jin Ko, Gwangju, KR;
Hyun You, Chungcheongbuk-do, KR;
Jung-hoon Yoon, Daejeon, KR;
Hyo-eun Yoon, Daejeon, KR;
Yong-Chul Kim, Gwangju, KR;
Hyo Jin Ko, Gwangju, KR;
Hyun You, Chungcheongbuk-do, KR;
Jung-Hoon Yoon, Daejeon, KR;
Hyo-Eun Yoon, Daejeon, KR;
Gwangju Institute of Science and Technology, Gwangju, KR;
Abstract
The present invention relates to a pheophorbide-α conjugate or its salt, solvate or hydrate. The pheophorbide-α conjugate of the present invention exhibiting fluorescence upon its introduction into cells and degradation inhibits the survival of various cancer cells. Especially, the conjugate of pheophorbide-α (1) and doxorubicin shows higher fluorescence intensity at lower pH (cancer environment). Therefore, the present composition for photodynamic therapy (PDT) of cancers is also very useful in detecting cancers. Interestingly, the anticancer effects of the present composition are dually exerted with help of both the photosensitizer and the anticancer drug of the present conjugates.