The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2015
Filed:
Jul. 26, 2010
Applicants:
Andreas Bikfalvi, Talence, FR;
Herve Prats, Toulouse Cedex, FR;
Cathy Quemener, Talence, FR;
Alexandre Dubrac, Toulouse Cedex, FR;
Inventors:
Andreas Bikfalvi, Talence, FR;
Herve Prats, Toulouse Cedex, FR;
Cathy Quemener, Talence, FR;
Alexandre Dubrac, Toulouse Cedex, FR;
Assignees:
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, FR;
Universite de Bordeaux, Bordeaux, FR;
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 9/10 (2006.01); C07K 14/52 (2006.01);
U.S. Cl.
CPC ...
C07K 14/522 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention pertains to PF4 muteins which comprise a substitution at position 67, e.g. a L67H substitution, compared to the sequence of the wild-type PF4 protein. Such PF4 muteins exhibit an increased anti-angiogenie activity and a reduced affinity for proteoglycans compared to the wild-type PF4 protein.