The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2015
Filed:
Feb. 01, 2010
Hidde L. Ploegh, Brookline, MA (US);
John M. Antos, Everett, WA (US);
Maximilian Wei-lin Popp, Pittsford, NY (US);
Carla Guimaraes, Boston, MA (US);
Hidde L. Ploegh, Brookline, MA (US);
John M. Antos, Everett, WA (US);
Maximilian Wei-Lin Popp, Pittsford, NY (US);
Carla Guimaraes, Boston, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Abstract
The present invention relates to methods for ligation. The invention provides novel reagents and methods for ligating an acyl donor compound with an acyl acceptor compound. Provided acyl donor compounds comprise a transamidase recognition sequence that allows ligation with a nucleophilic acyl acceptor in the presence of transamidase. The invention further provides kits comprising acyl donor compounds and optionally comprising other reagents for ligation.