The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2015
Filed:
Apr. 23, 2011
Charles E. Mckenna, Pacific Palisades, CA (US);
Boris A. Kashemirov, Los Angeles, CA (US);
Ivan S. Krylov, Los Angeles, CA (US);
Michaela Serpi, Cardiff, GB;
Valeria M. Zakharova, Los Angeles, CA (US);
Larryn W. Peterson, Mountain View, CA (US);
John M. Hilfinger, Ann Arbor, MI (US);
Charles E. McKenna, Pacific Palisades, CA (US);
Boris A. Kashemirov, Los Angeles, CA (US);
Ivan S. Krylov, Los Angeles, CA (US);
Michaela Serpi, Cardiff, GB;
Valeria M. Zakharova, Los Angeles, CA (US);
Larryn W. Peterson, Mountain View, CA (US);
John M. Hilfinger, Ann Arbor, MI (US);
University of Southern California, Los Angeles, CA (US);
Abstract
A tyrosine-based (phosphonylmethoxyalkyl)purine or -pyrimidine conjugate is provided. In some embodiments, the conjugate includes tyrosine based amino acid or dipeptide moieties of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine or its cytosine analog. A method of synthesizing such conjugates based on Boc-protected amino acid or dipeptides is also provided. In addition, a method of isomerizing an (S,S)-diastereoisomer to an (S,R)-diastereoisomer of an amino acid-based or dipeptide-based conjugate by a process including transesterification is provided. A method of inhibiting viral infection and a method of treating viral infection based on (phosphonylmethoxyalkyl)purine or -pyrimidine conjugates is also provided.