The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2015
Filed:
Dec. 20, 2011
Enrico Di Cera, Ladue, MO (US);
Andras Gruber, Portland, OR (US);
Prafull Gandhi, St. Louis, MO (US);
Leslie Pelc, Freeburg, IL (US);
Nicola Pozzi, St. Louis, MO (US);
David Collier Wood, Wildwood, MO (US);
Enrico Di Cera, Ladue, MO (US);
Andras Gruber, Portland, OR (US);
Prafull Gandhi, St. Louis, MO (US);
Leslie Pelc, Freeburg, IL (US);
Nicola Pozzi, St. Louis, MO (US);
David Collier Wood, Wildwood, MO (US);
Saint Louis University, St. Louis, MO (US);
Abstract
One aspect of the invention contemplates a mutant E-WE thrombin precursor that contains the SEQ ID NO:1 amino acid residue sequence. Another aspect contemplates a thrombin precursor that contains the amino acid residue sequence Asp/Glu-Gly-Arg at positions 325, 326 and 327 based on the preprothrombin sequence. A third aspect contemplates a thrombin precursor that contains the SEQ ID NO:1 amino acid residue sequence as well as the amino acid residue sequence Asp/Glu Gly Arg at positions 325, 326 and 327 based on the preprothrombin sequence. Also contemplated is a composition that contains an effective amount of mutant thrombin dissolved or dispersed in a pharmaceutically acceptable carrier. A method is also disclosed for enhancing treating and preventing thrombosis in a mammal in need using that composition.