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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8940286 B1

PDFFull Text
Date of Patent:
Jan. 27, 2015

Filed:

Jun. 22, 2010

Urate transporter, as well as method and kit for evaluating urate transport-related disease factor and inflammation-related disease factor, and test sample and drug

Applicants:

Hirotaka Matsuo, Saitama, JP;

Nariyoshi Shinomiya, Saitama, JP;

Takahiro Nakamura, Tokyo, JP;

Tappei Takada, Tokyo, JP;

Hiroshi Suzuki, Saitama, JP;

Yuki Ikebuchi, Tokyo, JP;

Kousei Ito, Tokyo, JP;

Kimiyoshi Ichida, Tokyo, JP;

Inventors:

Hirotaka Matsuo, Saitama, JP;

Nariyoshi Shinomiya, Saitama, JP;

Takahiro Nakamura, Tokyo, JP;

Tappei Takada, Tokyo, JP;

Hiroshi Suzuki, Saitama, JP;

Yuki Ikebuchi, Tokyo, JP;

Kousei Ito, Tokyo, JP;

Kimiyoshi Ichida, Tokyo, JP;

Assignees:

The University of Tokyo, Tokyo, JP;

Tokyo University of Pharmacy and Life Sciences, Tokyo, JP;

Attorneys:

Brian S. Boyer

Syndicated Law, PC

Primary Examiner:

Karen Cochrane Carlson

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 38/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); G01N 2800/34 (2013.01); G01N 33/566 (2013.01); G01N 2800/24 (2013.01); G01N 2800/32 (2013.01); G01N 33/6893 (2013.01);
Abstract

A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.

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