The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2015
Filed:
May. 04, 2009
Miloslav Karhanek, Santa Cruz, CA (US);
Chris D. Webb, Watsonville, CA (US);
Senkei Umehara, Santa Cruz, CA (US);
Nader Pourmand, Santa Cruz, CA (US);
Miloslav Karhanek, Santa Cruz, CA (US);
Chris D. Webb, Watsonville, CA (US);
Senkei Umehara, Santa Cruz, CA (US);
Nader Pourmand, Santa Cruz, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction withy peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of Il-10 at a concentration of 4ng/nl is also disclosed, as is detection of VEGF.