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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8937094 B1

PDFFull Text
Date of Patent:
Jan. 20, 2015

Filed:

Jul. 12, 2013

Triazole compounds that modulate hsp90 activity

Applicant:

Synta Pharmaceuticals Corp., Lexington, MA (US);

Inventors:

Joseph Burlison, Louisville, KY (US);

Shijie Zhang, Nashua, NH (US);

Weiwen Ying, Lexington, MA (US);

Dinesh U. Chimmanamada, Arlington, MA (US);

Minghu Song, Chester Springs, PA (US);

Junghyun Chae, Youngdengpo-yu, KR;

Stefan M. Schweizer, Memphis, TN (US);

Assignee:

Synta Pharmaceuticals Corp., Lexington, MA (US);

Attorneys:

McCarter & English, LLP

Steven G. Davis

Mei Bai

Primary Examiner:

Rebecca Anderson

Assistant Examiner:

Karen Cheng

Int. Cl.
CPC ...
A61K 31/4196 (2006.01); C07D 249/08 (2006.01); A61K 45/06 (2006.01); C07D 249/12 (2006.01); A61K 31/635 (2006.01); C07D 403/10 (2006.01); C07D 405/06 (2006.01); A61K 31/496 (2006.01); C07D 249/10 (2006.01); C07D 401/10 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); A61K 31/541 (2006.01); C07D 401/12 (2006.01); C07D 403/08 (2006.01); C07D 405/04 (2006.01); C07D 403/04 (2006.01); C07D 409/12 (2006.01); C07D 403/12 (2006.01); C07D 249/14 (2006.01); A61K 31/4439 (2006.01); A61K 31/5377 (2006.01); C07D 409/04 (2006.01); C07D 403/14 (2006.01); C07D 405/10 (2006.01); A61K 31/454 (2006.01);
U.S. Cl.
CPC ...
C07D 249/10 (2013.01); A61K 45/06 (2013.01); C07D 249/12 (2013.01); A61K 31/635 (2013.01); C07D 403/10 (2013.01); A61K 31/4196 (2013.01); C07D 405/06 (2013.01); A61K 31/496 (2013.01); C07D 401/10 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); A61K 31/541 (2013.01); C07D 401/12 (2013.01); C07D 403/08 (2013.01); C07D 405/04 (2013.01); C07D 249/08 (2013.01); C07D 403/04 (2013.01); C07D 409/12 (2013.01); C07D 403/12 (2013.01); C07D 249/14 (2013.01); A61K 31/4439 (2013.01); A61K 31/5377 (2013.01); C07D 409/04 (2013.01); C07D 403/14 (2013.01); C07D 405/10 (2013.01); A61K 31/454 (2013.01);
Abstract

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.

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