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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8937091 B1

PDFFull Text
Date of Patent:
Jan. 20, 2015

Filed:

May. 19, 2010

Inhibitor of protein crosslinking and use of the same

Applicants:

Katsuhiko Mikoshiba, Saitama, JP;

Kozo Hamada, Saitama, JP;

Akiko Terauchi, Saitama, JP;

Shouichirou Ozaki, Saitama, JP;

Jun-ichi Goto, Saitama, JP;

Etsuko Ebisui, Saitama, JP;

Akinobu Suzuki, Saitama, JP;

Inventors:

Katsuhiko Mikoshiba, Saitama, JP;

Kozo Hamada, Saitama, JP;

Akiko Terauchi, Saitama, JP;

Shouichirou Ozaki, Saitama, JP;

Jun-ichi Goto, Saitama, JP;

Etsuko Ebisui, Saitama, JP;

Akinobu Suzuki, Saitama, JP;

Assignee:

Japan Science and Technology Agency, Saitama, JP;

Attorney:

Foley & Lardner LLP

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
A61K 31/45 (2006.01); C07D 295/10 (2006.01); A61K 31/045 (2006.01); A61K 31/085 (2006.01); A61K 31/12 (2006.01); A61K 31/136 (2006.01); A61K 31/137 (2006.01); A61K 31/216 (2006.01); A61K 31/341 (2006.01); A61K 31/36 (2006.01); A61K 31/381 (2006.01); A61K 31/40 (2006.01); A61K 31/417 (2006.01); A61K 31/426 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4453 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/4965 (2006.01); A61K 31/5375 (2006.01); A61K 31/55 (2006.01);
U.S. Cl.
CPC ...
A61K 31/045 (2013.01); A61K 31/085 (2013.01); A61K 31/12 (2013.01); A61K 31/136 (2013.01); A61K 31/137 (2013.01); A61K 31/216 (2013.01); A61K 31/341 (2013.01); A61K 31/36 (2013.01); A61K 31/381 (2013.01); A61K 31/40 (2013.01); A61K 31/417 (2013.01); A61K 31/426 (2013.01); A61K 31/4402 (2013.01); A61K 31/4406 (2013.01); A61K 31/4409 (2013.01); A61K 31/4439 (2013.01); A61K 31/444 (2013.01); A61K 31/4453 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/4965 (2013.01); A61K 31/5375 (2013.01); A61K 31/55 (2013.01);
Abstract

The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein Ris a substituted or unsubstituted aryl or heterocyclyl group, R, R, and Rare hydrogen atoms, n is 2, X is halogen, Rand Rindependently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein Rand Rare not hydrogen atoms at the same time, or Rand Rmay be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.

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