The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 2015
Filed:
Dec. 19, 2007
Michael Ernest Marino, Clifton Park, NY (US);
Faisal Ahmed Syud, Clifton Park, NY (US);
Jason William Castle, Esperence, NY (US);
Brian Duh-lan Lee, Rexford, NY (US);
Malin Lindborg, Hagersten, SE;
Elin Gunneriusson, Saltsjobaden, SE;
Christofer Lendel, Farsta, SE;
Michael Ernest Marino, Clifton Park, NY (US);
Faisal Ahmed Syud, Clifton Park, NY (US);
Jason William Castle, Esperence, NY (US);
Brian Duh-Lan Lee, Rexford, NY (US);
Malin Lindborg, Hagersten, SE;
Elin Gunneriusson, Saltsjobaden, SE;
Christofer Lendel, Farsta, SE;
General Electric Company, Niskayuna, NY (US);
Abstract
Provided herein are methods of reducing liver uptake in vivo of a polypeptide that specifically binds to a target comprising: (a) providing a polypeptide that specifically binds to a target; and (b) substituting at least one basic or at least one neutral amino acid residue of the native polypeptide from step (a) with an acidic amino acid residue to produce a modified polypeptide, wherein the modified polypeptide demonstrates an isoelectric point at least 0.05-0.1 pH points less than the isoelectric point of the native polypeptide. Also provided are polypeptides made using the inventive methods as well as imaging techniques that employ the methods and agents.