The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 2015
Filed:
Nov. 15, 2013
Hao Zhang, New Berlin, WI (US);
Yang Shi, Wauwatosa, WI (US);
Hao Xu, Elm Grove, WI (US);
Kirkwood A. Pritchard, Jr., Elm Grove, WI (US);
Hao Zhang, New Berlin, WI (US);
Yang Shi, Wauwatosa, WI (US);
Hao Xu, Elm Grove, WI (US);
Kirkwood A. Pritchard, Jr., Elm Grove, WI (US);
The Medical College of Wisconsin, Inc., Milwaukee, WI (US);
Abstract
The present invention provides peptide-based peroxidase inhibitors having the formula AA-AA-AA, wherein AAis a positively charged, negatively charged or neutral amino acid, AAis a redox active amino acid, and AAis an amino acid possessing a reducing potential such that AAis capable of undergoing a redox reaction with a radical of amino acid AAor a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.