The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 2015
Filed:
Jun. 10, 2011
Andreas Mitsch, Lappersdorf-piehlmühle, DE;
Karl-hermann Schlingensiepen, Regensburg, DE;
Bernd Betzler, Aalen, DE;
Frank Jaschinski, Obertraubling, DE;
Anneliese Schneider, Feldafing, DE;
Andreas Mitsch, Lappersdorf-piehlmühle, DE;
Karl-Hermann Schlingensiepen, Regensburg, DE;
Bernd Betzler, Aalen, DE;
Frank Jaschinski, Obertraubling, DE;
Anneliese Schneider, Feldafing, DE;
Antisense Pharma GmbH, Regensburg, DE;
Abstract
Method for producing a modified oligonucleotide, wherein at least one polymer, preferably polyalkylene oxide, and/or a compound is covalently bound to the 5'-end or the 3′-end of the oligonucleotide via native ligation forming a native ligation site, with the proviso that the polymer and/or the compound is not a protein or peptide, if only the 5′-end of the oligonucleotide is modified by binding of the polymer or compound via native ligation. The invention is further directed to a modified oligonucleotide obtainable by the inventive method as well as the use of such modified oligonucleotide for the preparation of a medicament for preventing and/or treating a tumor, formation of metastasis, an immune disease or disorder, a cardiovascular disease or disorder, and/or a viral disease or disorder.