The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2015
Filed:
Sep. 22, 2011
Livius Cotarca, Cervignano del Friuli, IT;
Massimo Verzini, Caldiero, IT;
Elisa Melotto, Lonigo, IT;
Ivan Michieletto, Venice, IT;
Alfonso Melloni, Verona, IT;
Paolo Maragni, Virgilio, IT;
Raffaella Volpicelli, Vicenza, IT;
Mauro Andretto, Noventa Vicentina, IT;
Corrado Colli, Galliate, IT;
Livius Cotarca, Cervignano del Friuli, IT;
Massimo Verzini, Caldiero, IT;
Elisa Melotto, Lonigo, IT;
Ivan Michieletto, Venice, IT;
Alfonso Melloni, Verona, IT;
Paolo Maragni, Virgilio, IT;
Raffaella Volpicelli, Vicenza, IT;
Mauro Andretto, Noventa Vicentina, IT;
Corrado Colli, Galliate, IT;
Zach Systems S.p.A., Bresso (Milano), IT;
Abstract
The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.