The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 13, 2015

Filed:

May. 03, 2011
Applicants:

Daniel J. O'sullivan, Plymouth, MN (US);

Ju-hoon Lee, Roseville, MN (US);

Inventors:

Daniel J. O'Sullivan, Plymouth, MN (US);

Ju-Hoon Lee, Roseville, MN (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/195 (2006.01); A61K 38/00 (2006.01); A61K 9/14 (2006.01); C12N 1/20 (2006.01); A01N 63/02 (2006.01); A01N 63/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/195 (2013.01); A01N 63/00 (2013.01); A01N 63/02 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention provides isolated lantibiotics that inhibit. Gram negative and Gram positive microbes. The antibiotic includes an amino acid sequence, wherein the amino acid sequence of the compound and the amino acid sequence of SEQ ID NO:21 or SEQ ID NO:22 have at least 80% identity. The lantibiotics have the characteristic of inhibiting growth of a Gram negative microbe in conditions that do not damage the outer membrane of the Gram negative microbe. The present invention also provides methods for making and using the lantibiotics.


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