The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8933040 B1

PDF
Full Text
Expired
Date of Patent:
Jan. 13, 2015

Filed:

Nov. 08, 2011
Applicants:

Craig A. Coburn, West Point, PA (US);

Kun Liu, Rahway, NJ (US);

Ernest J. Mceacher, Burnaby, CA;

Changwei Mu, Beijing, CN;

Harold G. Selnick, West Point, PA (US);

David J. Vocadlo, Burnaby, CA;

Yaode Wang, Beijing, CN;

Zhongyong Wei, Beijing, CN;

Yuanxi Zhou, Burnaby, CA;

Inventors:

Craig A. Coburn, West Point, PA (US);

Kun Liu, Rahway, NJ (US);

Ernest J. McEacher, Burnaby, CA;

Changwei Mu, Beijing, CN;

Harold G. Selnick, West Point, PA (US);

David J. Vocadlo, Burnaby, CA;

Yaode Wang, Beijing, CN;

Zhongyong Wei, Beijing, CN;

Yuanxi Zhou, Burnaby, CA;

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08B 37/00 (2006.01); C07D 487/02 (2006.01); A61K 31/70 (2006.01); A61K 31/425 (2006.01); C07D 513/14 (2006.01); C07D 513/04 (2006.01); C07H 9/06 (2006.01); C07H 13/04 (2006.01); C07H 13/12 (2006.01); C07H 15/18 (2006.01); C12Q 1/48 (2006.01);
U.S. Cl.
CPC ...
C07D 513/14 (2013.01); C07D 513/04 (2013.01); C07H 9/06 (2013.01); C07H 13/04 (2013.01); C07H 13/12 (2013.01); C07H 15/18 (2013.01); C12Q 1/48 (2013.01); G01N 2500/02 (2013.01);
Abstract

The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.


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