The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 13, 2015

Filed:

Feb. 06, 2012
Applicants:

Tomasz Glinka, Cupertino, CA (US);

Robert Higuchi, Solana Beach, CA (US);

Scott Hecker, Del Mar, CA (US);

Brian Eastman, San Diego, CA (US);

Olga Rodny, Mill Valley, CA (US);

Inventors:

Tomasz Glinka, Cupertino, CA (US);

Robert Higuchi, Solana Beach, CA (US);

Scott Hecker, Del Mar, CA (US);

Brian Eastman, San Diego, CA (US);

Olga Rodny, Mill Valley, CA (US);

Assignee:

Rempex Pharmaceuticals, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 31/04 (2006.01); C07K 5/06 (2006.01); C07F 5/02 (2006.01); A61K 38/05 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06191 (2013.01); C07F 5/025 (2013.01); A61K 38/05 (2013.01);
Abstract

Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.


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