The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2015
Filed:
Aug. 08, 2011
John Limanto, Metuchen, NJ (US);
Gregory Beutner, Green Brook, NJ (US);
Brendan Grau, Warrington, PA (US);
Jacob Janey, New York, NY (US);
Artis Klapars, Edison, NJ (US);
Eric R. Ashley, Fanwood, NJ (US);
Hallena R. Strotman, Monmouth Junction, NJ (US);
Matthew D. Truppo, Ocean Township, NJ (US);
Gregory Hughes, Scotch Plains, NJ (US);
Fabien Cabirol, Dusseldorf, DE;
Anupam Gohel, Singapore, SG;
Steven J. Collier, Singapore, SG;
Jack Liang, San Mateo, CA (US);
Marissa Mock, Moorpark, CA (US);
Emily Mundorff, Poughkeepsie, NY (US);
Scott Novick, Palo Alto, CA (US);
Derek Smith, Singapore, SG;
John Limanto, Metuchen, NJ (US);
Gregory Beutner, Green Brook, NJ (US);
Brendan Grau, Warrington, PA (US);
Jacob Janey, New York, NY (US);
Artis Klapars, Edison, NJ (US);
Eric R. Ashley, Fanwood, NJ (US);
Hallena R. Strotman, Monmouth Junction, NJ (US);
Matthew D. Truppo, Ocean Township, NJ (US);
Gregory Hughes, Scotch Plains, NJ (US);
Fabien Cabirol, Dusseldorf, DE;
Anupam Gohel, Singapore, SG;
Steven J. Collier, Singapore, SG;
Jack Liang, San Mateo, CA (US);
Marissa Mock, Moorpark, CA (US);
Emily Mundorff, Poughkeepsie, NY (US);
Scott Novick, Palo Alto, CA (US);
Derek Smith, Singapore, SG;
Codexis, Inc., Redwood City, CA (US);
Abstract
The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.