The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 13, 2015

Filed:

Jun. 28, 2013
Applicant:

Vaxinnate Corporation, Cranbury, NJ (US);

Inventors:

Langzhou Song, Cranbury, NJ (US);

Ge Liu, Cranbury, NJ (US);

Scott Umlauf, Cranbury, NJ (US);

Uma Kavita, Cranbury, NJ (US);

Hong Li, Cranbury, NJ (US);

Xiangyu Liu, Cranbury, NJ (US);

Bruce Weaver, Cranbury, NJ (US);

Lynda Tussey, Cranbury, NJ (US);

Assignee:

VaxInnate Corporation, Cranbury, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/62 (2006.01); C07K 14/005 (2006.01); C07K 14/255 (2006.01); A61K 39/145 (2006.01); A61K 39/39 (2006.01); C07K 14/195 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/145 (2013.01); A61K 39/39 (2013.01); C07K 14/255 (2013.01); C07K 14/195 (2013.01); C07K 2319/00 (2013.01); C07K 2319/40 (2013.01); C07K 2319/74 (2013.01); A61K 2039/6068 (2013.01); C12N 2760/16234 (2013.01); C12N 2760/16222 (2013.01);
Abstract

Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin.


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